HAZMAT/Chemicals
  Posted on: Tuesday, April 11, 2017
Enzymes versus nerve agents: Designing antidotes for chemical weapons
Homeland Security News Wire

Nerve agents, a class of synthetic phosphorous-containing compounds, are among the most toxic substances known. Brief exposure to the most potent variants can lead to death within minutes. Once nerve agents enter the body, they irreversibly inhibit a vitally important enzyme called acetylcholinesterase. Its normal job within the nervous system is to help brain and muscle communicate. When a nerve agent shuts down this enzyme, classes of neurons throughout the central and peripheral nervous systems quickly get overstimulated, leading to profuse sweating, convulsions and an excruciating death by asphyxiation. There is a path to mitigate the danger of chemical weapons. This route lies within the domains of science – the very same science that produced chemical weapons in the first place. Researchers in the United States and around the world are developing the tools needed to quickly and safely destroy nerve agents – both in storage facilities and in the human body. There are promising advances, but no enzyme yet exists which is efficient enough for lifesaving use in people. It is worth keeping in mind the awesome and often complex power of science, however: We may be only a few years away from developing the kind of therapeutics that would make chemical weapons a worry of the past.


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HAZMAT/Chemicals:
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